Explain X chromosome inactivation

Solution:

Barr body is defined as the inactive X chromosome in the somatic cell of a female. Number of barr body is always equal to total number of X chromosome minus 1. X inactivation occurs randomly during embryonic development. If a foetus has one active X chromosome and one inactive X chromosome, that means the child is a female. For male, a single Y chromosome is sufficient to determine that the child is a male.
  
X chromosome inactivation refers to the permanent inactivation or transcriptional silencing of one the two X-chromosomes in the female during the early embryonic stage. 

 

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