can plz explain the life cycle of plasmodium...?
The life cycle of plasmodium-
- Plasmodium requires two hosts to complete its life cycle.
- When a female Anopheles mosquito bites a healthy human being, it releases Plasmodium, which lives in its body as sporozoite (infectious form).
- The parasites multiply (asexual reproduction) in the liver cells and finally burst the liver cells. Sporozoites are released in the blood.
- Parasites enter RBCs and further multiply (asexual reproduction) here and finally burst RBCs also.
- Bursting of RBCs is accompanied by the release of a toxic substance called hemozoin (associated with fever and chills).
- In the RBCs, only sporozoites change into gametocytes (sexual stage). Gametocytes multiply.
- When the diseased person is bitten by a female Anopheles mosquito, gametocytes are introduced into the mosquito.
- Gametocytes fertilize and develop inside the intestine of the mosquito to form sporozoites.
- Sporozoites are stored in the salivary glands of mosquito and are released into the healthy person who is bitten by this mosquito.
Hence, the parasite firstly infects the liver cells and then the RBCs.